ICBAS - Instituto de Ciências Biomédicas Abel Salazar
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Diet has impacts on fertility that can be inherited for two generations

Parents' food choices may have consequences on their children's health.

Um estudo desenvolvido por investigadores do Instituto de Ciências Biomédicas Abel Salazar (ICBAS), no Porto, concluiu que a alimentação produz impactos na fertilidade masculina que podem ser transmitidos e herdados por duas gerações.

O instituto revela que no estudo, publicado na revista “Molecular Nutrition & Food Research“, researchers from the Multidisciplinary Unit of Biomedical Research at ICBAS described the biomarkers that make it possible to identify a “metabolic memory” present in the testes.

The alterations are “consequences of eating a high-fat diet” and can be inherited by two generations, that is, father-son-grandson, having “implications on male fertility”. 

Marco Alves and Luís Crisóstomo, in the center of the image, at the PhD defense of ICBAS student, accompanied by the jury and the entire research team.

A equipa, liderada pelo investigador Marco Alves, já tinha determinado, em trabalhos anteriores, que a ingestão excessiva de gordura durante as primeiras fases da vida altera o conteúdo lípido e o metabolismo dos testículos, “afetando negativamente a capacidade reprodutiva durante o resto da vida” e “resultando em alterações que não são reversíveis com a mudança para uma dieta equilibrada”.

In this study, carried out in animal models (mice), the researchers “went further” and described the transgenerational effects that are transmitted by parents who eat a diet rich in fats to children and grandchildren who follow a balanced diet. 

 “The offspring showed, in the testicles, an alteration in the metabolism of choline”, an essential nutrient for the regulation of various functions, such as brain function, and the development of spermatozoa.

The investigation also showed alterations in the activity of mitochondria, in antioxidant defenses and in the presence of various lipids. 

"These alterations promote a proinflammatory environment in the testicle, altering sperm count and quality", stresses the researcher, noting that transgenerational effects are also observed when the father's intake of fat is only until puberty. 

The researcher Marco Alves points out that reproduction “is also a reflection of diet”. 

“Our food choices will have consequences for our children and, very possibly, for our grandchildren as well”, he says, adding that these effects may have even more impact on assisted reproduction processes, since the spermatozoon is chosen randomly and without taking into account biomarkers such as those identified in the study.

“The increase in infertility is clearly associated with the increase in metabolic diseases (overweight, obesity and diabetes, among others), and this association has already been recognized by the World Health Organization”, highlights Marco Alves. 

The metabolic memory in the testis is transmitted by the Sertoli cells, which respond to ensure all the structural and metabolic needs during the sperm formation process. 

The stimuli captured by these cells, in addition to altering their own genetic expression, also alter the epigenetics. 

“Knowing these changes and the transmission mechanisms will allow selecting the best spermatozoa and the best window of time to perform in vitro fertilization, improving the efficiency of assisted reproduction techniques and opening up new therapeutic opportunities in male infertility”, adds the researcher.

Além da equipa do ICBAS, o estudo contou também com investigadores da Faculdade de Farmácia da Universidade do Porto, da Universidade de Aveiro, do Instituto Politécnico da Guarda e da Associação Protetora dos Diabéticos de Portugal (APDP).

The work also resulted from several international partnerships, including the University of Zagreb and the University College of London.

Source: CNN Portugal

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Vaccines – a One Health super tool!

By Begoña Pérez-Cabezas, ICBAS

PORTO - Smallpox, caused by the variola virus, was one of the most devastating infectious diseases for humanity. The smallpox vaccine, created by Edward Jenner in 1796, was the first successful vaccine to be developed. Jenner observed that milkmaids who previously suffered from cowpox did not develop smallpox, and showed that a similar inoculation could be used to prevent smallpox in humans. This link between a veterinary and a human disease, established by a farmer and a physician, is an example of ther One Health approach.
Vaccines are one of the most important tools for infectious disease prevention, control and eradication. But vaccinating only people is not enough to ensure the health of all. Animal vaccines are an essential barrier to prevent the transmission of some zoonoses - diseases that spread from animals to humans. Their use can control diseases in companion and domesticated animals, such are, for instance, the Rift Valley fever and rabies. They are also useful to ensure safe food supplies through maintaining healthy livestock populations. One case in point is the vaccination of poultry against Salmonella.
But the benefits of vaccination do not stop here! Vaccines are also key for reducing antimicrobial use and to prevent the emergence and spread of drug resistance which affects the human, animal, and environmental sectors. And their use also plays a beneficial role in climate change, as the increase of animal productivity diminish the Greenhouse gas emission per kg of animal food produced.
Vaccination has a big impact on everyone's health. Be part of the solution and get vaccinated!

Image Credits: Mat Napo, Unsplash.

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Events

2nd Porto One Health Day

International One Health Day at ICBAS

3 de novembro de 2022, 14h

No próximo dia 3 de novembro, Dia Internacional Uma Saúde, o Instituto de Ciências Biomédicas Abel Salazar (ICBAS) da Universidade do Porto vai voltar a reunir especialistas das mais variadas áreas e instituições do país para promover o debate em torno de uma abordagem holística da Saúde.

Este ano, com um programa mais direcionado para a comunidade não científica, o 2nd Porto One Health Day reflete o esforço que a instituição tem vindo a fazer para promover e difundir o conceito One Health/Uma Saúde entre a comunidade científica, académica e a sociedade civil.

As comemorações terminam com a inauguração da exposição ‘Perspetiva(s) sobre Uma Saúde’, na Estação de Metro dos Aliados, às 18h45.

Inscrições here.

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Events

Photography Exhibition ‘Perspective(s) on One Health’ at CPF

This is a selection of images that portray the integrated vision of Health that ICBAS has been promoting. It is a result of the homonymous photography contest that took place in March and April 2022.

The photography contest 'Perspective(s) on One Health' promoted the dissemination of the concept among the academic community of U. Porto. About 250 images were received, from which ICBAS, together with the Portuguese Institute of Photography (IPF), a partner in this project, selected 20 photographs for a traveling exhibition which will be in several places in Porto.

The exhibition can be visited now at Centro Português de Fotografia (CPF), between October 3rd and 30th (Antiga Cadeia e Tribunal da Relação do Porto, Largo Amor da Perdição, 4050-008 Porto). Entrance is free.

This exhibition is an opportunity to promote a joint reflection on the One Health concept, as well as to alert civil society to the impact we all have on human, animal and environmental health.

See the exhibition sheet here.

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Events

Photography Exhibition 'Perspective(s) on One Health' at ICBAS

This is a selection of images that portray the integrated vision of Health that ICBAS has been promoting. It is a result of the homonymous photography contest that took place in March and April 2022.

The photography contest 'Perspective(s) on One Health promoted the dissemination of the concept among the academic community of U. Porto. About 250 images were received, from which ICBAS, together with the Portuguese Institute of Photography (IPF), a partner in this project, selected 20 photographs for a traveling exhibition which will be in several places in Porto.

The exhibition can now be visited at ICBAS, located in different parts of the School, between 12 September and 4 November (R. Jorge de Viterbo Ferreira 228, 4050-313 Porto).

This exhibition is an opportunity to promote a joint reflection on the One Health concept, as well as to alert civil society to the impact we all have on human, animal and environmental health.

See the exhibition sheet here.

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Noticias

ICBAS and ISPUP launch the 'Pet-OncoNet' website for owners of pets with cancer

The aim is that owners find “credible, accurate and useful” information. There are also data about dog breeds with a greater predisposition to the development of tumors and ways to detect them early.

Professors and researchers from the Instituto de Ciências Biomédicas Abel Salazar (ICBAS) and the Instituto de Saúde Pública da Universidade do Porto (ISPUP) launched an online platform for the owners of companion animals with cancer, which aims to provide “credible” information and characterize risk factors associated with the development of the disease.

Speaking to Lusa, Kátia Pinello, Professor at ICBAS and researcher at ISPUP, clarified that the website, entitled ‘Pet-OncoNet’, arises from the logic of the ‘One Health’ concept and the need to fill a "knowledge gap in this area”.

“We feel that tutors feel lost when dealing with the diagnosis of cancer in their animal companions”, said the researcher, who is one of the project coordinators. 

Launched to provide "credible, accurate and useful" information about companion animals, the digital platform includes, for example, data on dog breeds with a greater predisposition to the development of tumors, ways to detect cancer early in pets, and also information on ongoing clinical trials and procedures to support the animal during treatment.

“Our goal is to create a community that studies and shares information about veterinary oncology in all aspects", referred.

The website shows that in Portugal, the main tumors in pets are located in the skin, followed by mammary tumors.

In addition to providing information, the platform's objective is also to characterize the risk factors associated with the development of cancer in animals and humans.

"Increasingly, animals are active members of the family. This change in attitude towards animals makes them good research models and considered 'sentinels' for cancer, since they are closer and share the same environment as humans", indicated. 

In order to make it possible to proceed with the characterization of risk factors, the researchers are inviting all tutors and owners of companion animals – cats and dogs – to respond to an epidemiological inquiry, which will be available on the website until the end of October.

The results obtained in the context of the survey will later be published on the initiative's website.

The researchers also want to create a “psychological support group” to help guardians deal with animal grief, an issue that “is not yet very well accepted”. 

“Animal grief has implications for public health”, he noted, adding that “it is important to know how to face animal grief”. 

In order to continue the project, however, the researchers need financial help, which is why it is planned to open a crowdfunding campaign on the Pet-OncoNet website.

The site, developed in partnership with Oncowaf and financed by the Belgian fund for animals with cancer, is one of the interfaces of the network Vet-OncoNet, launched in December 2019, with the aim of gathering information on neoplasms present in companion animals and creating an animal oncological registry at national level.

With the collaboration of veterinarians and diagnostic laboratories that joined the project, researchers have been able to create an animal oncology registry. The objective now is to involve owners in this network, in order to better understand the common risk factors for development of cancer in animals and humans.

Source: CNN Portugal

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Events

Photography Exhibition ‘Perspective(s) on One Health’

From June to December 2022 at various locations in Porto

On the 1st of June it opens at the Biodiversity Gallery – Centro Ciência Viva | Museum of Natural History and Science of the U. Porto, the traveling exhibition 'Perspective(s) on One Health'. This is a selection of 20 images, which portray the integrated vision of Health that ICBAS has been promoting, as a result of the homonymous photography contest that took place in March and April.

From the ‘Perspective(s) on One Health’ photo contest, which aimed to promote the dissemination of the concept among the U. Porto academic community, around 250 images were received. Of these, ICBAS, together with the Portuguese Institute of Photography (IPF), a partner in this initiative, selected 20 photographs for an itinerant exhibition that will take place in various locations in Porto:

  1. From June 2nd to July 3rd – Biodiversity Gallery
  2. July to September – ICBAS
  3. October – Portuguese Photography Center (CPF)
  4. November – Metro od Porto
  5. December – Círculo Universitário do Porto

This exhibition is an opportunity to promote a joint reflection on the One Health concept, as well as to alert civil society to the impact we all have on human, animal and environmental health.

The exhibition 'Perspective(s) on One Health' can be visited, from June 2nd to July 3rd, from Tuesday to Sunday, from 10:00 to 13:00 and from 14:00 to 18:00, at Biodiversity Gallery – Centro Ciência Viva | Museum of Natural History and Science of the U. Porto (Rua do Campo Alegre 1191, 4150-181 Porto).

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Noticias

ICBAS announces winners of the ‘Perspective(s) on One Health’ contest

With the aim of promoting and disseminating the One Health concept throughout the community and civil society, the 'Instituto de Ciências Biomédicas Abel Salazar' of the University of Porto (ICBAS), together with the 'Instituto Português de Fotografia' (IPF), organized the Photography Contest ‘Perspective(s) on One Health’.

In the context of this contest, Teresa Nunes, photographer at IPF, wrote the following text, in order to frame and defend photography as a cultural tool:

‘Artivism’ – photography as a cultural tool

Art has always worked as a reflection of society, following reality over time, recording it, but also acting as an instrument of change. It is called “artivism”, a portmanteau [1] coming from the junction of the words “art” and “activism”. There is an extensive range of artists, in the most diverse artistic disciplines, who assume themselves as artivists, advocating for the most different causes.

Naturally, Photography is no exception, appearing as fertile ground for artivists. In a first analysis, it can be assumed that photographers related to artivism will be linked to documentary photography and photojournalism, but this is a reductive view. Although, effectively, this area of photography, which strives for the representation of the real without manipulations or alterations, is quite prone to artivism, other photographers, who depart from the canons of photojournalism, also fit into the concept. Whatever the area of photography, currently photographers are mobilized by the ability of photography to show the public and political agents issues in which the intervention and awareness of society is necessary.

Anthony Luvera, who was recently in Porto to speak at the lecture “Photography and Social Activism”, within the scope of the 'Encontros do Olhar' conversation cycle “Fragility – Transitoriedade”, organized by the Portuguese Institute of Photography, works with individuals and groups of marginalized people by inviting them to talk about their experiences, creating with them collaborative projects in areas such as mental health, addictions, homelessness and the LGBTQ+ community.

Eduardo Leal, with his series “Plastic Trees”, portrays pollution in the Bolivian Altiplano, demonstrating his concern for environmental issues. The author opted for an aestheticization of pollution as an alternative to traditional means of reporting, photographing plastic bags, one of the most used consumer items and which ends up becoming one of the biggest sources of pollution worldwide. With this work, he intended to draw attention to the problem of pollution, focusing on an area where thousands of bags wander with the wind until they end up stuck in the bushes, damaging the landscape.

Von Wong, known worldwide for his hyper-realistic works, staged and assembled with the help of his team and a multitude of volunteers who join the artist in each project. This one starts by setting up grandiose scenarios for his photographs that are always designed to raise awareness of issues such as pollution and excessive use of plastic, recycling and animal welfare, among others.

We can see that many authors fight for different causes with which they identify and that, to the most inattentive eyes, may seem disconnected and with no apparent reason to be the target of attention of the same people, however, it is increasingly commonly accepted that we all live on a planet in which everything is interconnected and issues of human, animal and environmental health are interconnected, explaining relationships that could, at first glance, seem almost unreasonable, is, after all, the One Health.

It is therefore to be concluded that photography can and should be understood as a cultural tool capable of communicating a message of awareness and inducing changes. In an era where civic participation is increasingly necessary to encourage changes in the society we live in, it is increasingly common to see photographers joining these causes in order to make use of their greatest tool to support them. 

[1] Palavra fantasista formada por elementos de outras duas (Dicionário infopédia de Inglês – Português [em linha]. Porto: Porto Editora. Disponível em https://www.infopedia.pt/dicionarios/ingles-portugues/portmanteau)

During the celebrations of 47th anniversary of ICBAS, held on May 5, 2022, the institution took the opportunity to announce the winners of the contest

Honorable mention:

Photography by Rui Maneiras, Alumno ICBAS

Third prize:

Inês Martinho, Alumna ICBAS

Second prize:

Telma Costa, Alumna ICBAS

First prize:

Teresa Leão, Professor at the Faculty of Medicine of the University of Porto (FMUP)
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Events

Projeto ‘Liga-te à Terra’

O projeto ‘Liga-te à Terra’ foi desenvolvido pelo Grupo de Investigação de Saúde e Bem-Estar One Health do ICBAS, em parceria com o Gabinete de Apoio ao Estudante (GAE-ICBAS), com o objetivo de promover o bem-estar dos nossos estudantes.

A ciência diz-nos que, mais do que passar tempo na natureza, entrar em relação com ela traz-nos imensos benefícios. Serena a mente, restaura a capacidade de atenção, dá alegria e até fortalece o sistema imunitário.

Inspirados na campanha “30 Days Wild” – implementada anualmente no Reino Unido – os investigadores do ICBAS querem desafiar os estudantes a entrarem em relação com os elementos da natureza que os rodeiam, durante 30 dias.

Queres saber mais? Preenche o seguinte formulário ou envia e-mail para a investigadora responsável, Karine Silva (cssilva@icbas.up.pt).

Inscrições até 30 de abril de 2022.

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Noticias

Porto is the region with most seagulls in the country

Metropolitan Area is drawing up a plan to respond to the phenomenon. Only in the cities along the Douro there are more than a thousand birds and they are breeding.

Never so many seagulls have inhabited the city of Porto. There will be between 1186 and 1626 seagulls flying over the Porto Metropolitan Area (AMP), according to the National Census of the Portuguese Society for the Study of Birds (SPEA). It is the largest number of seagulls in an urban environment in the country. And with bird breeding on the rise, the trend is to continue to rise. Matosinhos and Gaia also suffer from the problem, which translates into public health risks. A metropolitan plan to control the seagull population is being prepared, the report of which will be published shortly.


One of the measures that may be on the table is an eventual operation to remove eggs from the nests. However, as seagulls have an average life cycle of 20 years, the result of this work will take time to reveal itself. “In the late 1990s, seagulls began to expand to the north and exclusively to urban areas. When they successfully reproduce in a place, they always come back”, notes Nuno Oliveira, marine conservation technician at SPEA. The removal of eggs will always be “a lengthy process, which requires human and financial resources”, he adds, warning that during the first three or four years of life, seagulls do not reproduce.


Contamination Source
Easy access to food is the main reason for the movement of seagulls from the Center and South to the North of the country and their incessant reproduction is a risk to public health. That's the same alert that makes Adriano Bordalo e Sá, hydrobiologist and researcher od the Instituto de Ciências Biomédicas Abel Salazar (ICBAS): “They have the same pathogenic bacteria in their excrement as we do and are a clear source of water and soil contamination and disease transmission”.


“The explosion of food availability”, almost “without limitation”, leads to an increase in the population of seagulls, points out Nuno Oliveira, who notes “a great effort to improve waste management and temporary storage”. Fishing waste also feeds these animals, particularly thanks to the amount of already dead fish that are returned to the sea.


“It's free food for the seagulls. And there are eight thousand fishing vessels in the country”, notes Nuno Oliveira. The first step, says Bordalo e Sá, is the launch of “a campaign not to feed the seagulls, in the same way that there was one not to feed the pigeons”. Nuno Oliveira agrees.


To decide on strategies to combat the problem, AMP launched, two years ago, a public tender, with a base price of 135 thousand euros, for the elaboration of a population control plan. That work will be over.


The last study, published in 2011, pointed to the decrease in available food as one of the solutions.

Source: Jornal de Notícias
Text: Adriana Castro

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