ICBAS - Instituto de Ciências Biomédicas Abel Salazar

ICBAS leads a One Health project for the safe use of antimicrobials

The USAM SULEI project will invest more than 850 thousand euros in promoting the safe use of antimicrobials in the production of pigs and bovine milk.

Monitoring, raising awareness, and providing information on good practices associated with the safe use of antimicrobials in the production of pigs and bovine milk is the aim of the USAM SULEI project, led by the Instituto de Ciências Biomédicas Abel Salazar (ICBAS) of the University of Porto, and co-financed by the European Union through the Recovery and Resilience Plan (PRR).

For the project's main researcher and ICBAS professor, João Niza Ribeiro, "the funding received –more than 850 thousand euros – will allow the development and implementation of an integrated online system (web platform) to support decision-making in the use of antimicrobials, aimed at veterinarians and producers, with the objective of sustainably reducing the consumption of antibiotics on pig farms and in dairy farming”.

Read the full text here.

Source: Notícias UP; Image: Amber Kipp via unsplash.


The ecology of antimicrobial resistance

Microbiology has made a decisive contribution to the development of the One Health, particularly when combined with advanced microbial genomic tools. Through them, we can investigate outbreaks (e.g. Salmonella spp., Campylobacter jejuni), monitor variants of pathogenic microorganisms or understand the global circulation of bacteria and resistance genes between the human, animal and environmental biome. In fact, the bacterial species that we are most concerned about in terms of resistance (ESKAPE*) share three characteristics: (i) can colonize more than one animal species, (ii) behave mostly like commensal (e.g., are able to colonize the intestine or skin of humans and animals without causing any disease), and (iii) have a remarkable eco-resistance, being able to survive on inert surfaces, in soil or in water for a long time. Therefore, they are able to “travel” between different hosts, demonstrating that without a holistic view we will not be able to contain them.

Under this perspective, the microLAB Laboratory of the Aquatic Production Department of ICBAS – in collaboration with companies, institutions and other research groups – has been studying:

1. The presence of multi-resistant Enterobacteriaceae in different animal populations (chickens, gulls, birds of prey, wolves, bivalves, sea urchins, rabbits, dogs and cats), in humans (pet owners) and in the environment (stations of wastewater treatment, rivers, beaches, lakes and city fountains);

2. The antibacterial activity of hundreds of chemical compounds isolated in cyanobacteria and marine fungi or modified/generated by chemical synthesis processes, provided by collaborating research groups;

3. The phylogenetic proximity between bacteria isolated from humans and bacteria obtained from trains and buses (Staphylococcus aureus resistant to methicillin-MRSA) or in chickens and dogs (Campylobacter jejuni).

*Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.

To know more:

Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrug resistant Gram-positive bacterial infections

Campylobacter jejuni in Different Canine Populations: Characteristics and Zoonotic Potential

Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors

Contact: Professor Paulo Martins da Costa (pmcosta@icbas.up.pt)

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